E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1

Metastasis-associated protein 1 (MTA1), a component of the nucleosome remodeling and histone deacetylation (NuRD) complex, is widely upregulated in human cancers. However, the mechanism for regulating its protein stability remains unknown. Here we report that MTA1 is an ubiquitinated protein and tar...

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Autors principals: Li, Da-Qiang, Ohshiro, Kazufumi, Reddy, Sirigiri Divijendra Natha, Pakala, Suresh B., Lee, Mong-Hong, Zhang, Yanping, Rayala, Suresh K., Kumar, Rakesh
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762678/
https://ncbi.nlm.nih.gov/pubmed/19805145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908027106
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