Overexpression of VEGF-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy

Vascular Endothelial Growth Factor-B (VEGF-B) is poorly angiogenic but prominently expressed in metabolically highly active tissues, including the heart. We produced mice expressing a cardiac-specific VEGF-B transgene via the alpha myosin heavy chain promoter. Surprisingly, the hearts of the VEGF-B...

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Main Authors: Karpanen, Terhi, Bry, Maija, Ollila, Hanna M., Seppänen-Laakso, Tuulikki, Liimatta, Erkki, Leskinen, Hanna, Kivelä, Riikka, Helkamaa, Teemu, Merentie, Mari, Jeltsch, Michael, Paavonen, Karri, Andersson, Leif C., Mervaala, Eero, Hassinen, Ilmo E., Ylä-Herttuala, Seppo, Orešič, Matej, Alitalo, Kari
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762522/
https://ncbi.nlm.nih.gov/pubmed/18757827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.178459
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