Study of Human RIG-I Polymorphisms Identifies Two Variants with an Opposite Impact on the Antiviral Immune Response

BACKGROUND: RIG-I is a pivotal receptor that detects numerous RNA and DNA viruses. Thus, its defectiveness may strongly impair the host antiviral immunity. Remarkably, very little information is available on RIG-I single-nucleotide polymorphisms (SNPs) presenting a functional impact on the host resp...

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Detalhes bibliográficos
Main Authors: Pothlichet, Julien, Burtey, Anne, Kubarenko, Andriy V., Caignard, Gregory, Solhonne, Brigitte, Tangy, Frédéric, Ben-Ali, Meriem, Quintana-Murci, Lluis, Heinzmann, Andrea, Chiche, Jean-Daniel, Vidalain, Pierre-Olivier, Weber, Alexander N. R., Chignard, Michel, Si-Tahar, Mustapha
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762520/
https://ncbi.nlm.nih.gov/pubmed/19859543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007582
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