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Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain

Sec7 domains (Sec7d) catalyze the exchange of guanine nucleotide on ARFs. Recent studies indicated that brefeldin A (BFA) inhibits Sec7d-catalyzed nucleotide exchange on ARF1 in an uncompetitive manner by trapping an early intermediate of the reaction: a complex between GDP-bound ARF1 and Sec7d. Usi...

詳細記述

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書誌詳細
主要な著者: Robineau, Sylviane, Chabre, Marc, Antonny, Bruno
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 2000
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC27624/
https://ncbi.nlm.nih.gov/pubmed/10954741
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