Kinetics of Interaction between ADP-ribosylation Factor-1 (Arf1) and the Sec7 Domain of Arno Guanine Nucleotide Exchange Factor, Modulation by Allosteric Factors, and the Uncompetitive Inhibitor Brefeldin A

The GDP/GTP nucleotide exchange of Arf1 is catalyzed by nucleotide exchange factors (GEF), such as Arno, which act through their catalytic Sec7 domain. This exchange is a complex mechanism that undergoes conformational changes and intermediate complex species involving several allosteric partners su...

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Detalhes bibliográficos
Main Authors: Rouhana, Jad, Padilla, André, Estaran, Sébastien, Bakari, Sana, Delbecq, Stephan, Boublik, Yvan, Chopineau, Joel, Pugnière, Martine, Chavanieu, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576071/
https://ncbi.nlm.nih.gov/pubmed/23255605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391748
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