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Rapid Oxime and Hydrazone Ligations with Aromatic Aldehydes for Biomolecular Labeling

A high yielding and rapid chemoselective ligation approach is presented that uses aniline catalysis to activate aromatic aldehydes towards two amine nucleophiles, namely 6-hydrazinopyridyl and aminooxyacetyl groups. The rates of these ligations are resolved for model reactions with unprotected pepti...

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Autori principali: Dirksen, Anouk, Dawson, Philip E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761707/
https://ncbi.nlm.nih.gov/pubmed/19053314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc800310p
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