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Characterization of mutant MUTYH proteins associated with familial colorectal cancer

BACKGROUND & AIMS: The human mutyh gene encodes a base excision repair (BER) protein that prevents G:C to T:A transversions in DNA. Biallelic mutations in this gene are associated with recessively inherited familial colorectal cancer. The aim of this study was to characterize the functional acti...

詳細記述

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書誌詳細
主要な著者: Ali, Mohsin, Kim, Hyeja, Cleary, Sean, Cupples, Claire, Gallinger, Steven, Bristow, Robert
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761659/
https://ncbi.nlm.nih.gov/pubmed/18534194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.04.035
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