Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas

We previously reported that central nervous system (CNS) inactivation of Nf1 and p53 tumor suppressor genes in mice results in the development of low-grade to high-grade progressive astrocytomas. When the tumors achieve high grade, they are frequently accompanied by Akt activation, reminiscent of th...

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Bibliographic Details
Main Authors: Kwon, Chang-Hyuk, Zhao, Dawen, Chen, Jian, Alcantara, Sheila, Li, Yanjiao, Burns, Dennis K., Mason, Ralph P., Lee, Eva Y.-H. P., Wu, Hong, Parada, Luis F.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760841/
https://ncbi.nlm.nih.gov/pubmed/18451155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6867
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