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Cysteine pK(a) Depression by a Protonated Glutamic Acid in Human DJ-1
Human DJ-1, a disease-associated protein that protects cells from oxidative stress, contains an oxidation-sensitive cysteine (C106) that is essential for its cytoprotective activity. The origin of C106 reactivity is obscure, due in part to the absence of an experimentally determined pK(a) value for...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760839/ https://ncbi.nlm.nih.gov/pubmed/18570440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800282d |
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