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Discovery and Development of a Small Molecule Library with Lumazine Synthase Inhibitory Activity
(E)-5-Nitro-6-(2-hydroxystyryl)pyrimidine-2,4(1H,3H)-dione (9) was identified as a novel inhibitor of Schizosaccharomyces pombe lumazine synthase by high-throughput screening of a 100,000 compound library. The K(i) of 9 vs. Mycobacterium tuberculosis lumazine synthase was 95 μM. Compound 9 is a stru...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760403/ https://ncbi.nlm.nih.gov/pubmed/19552377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo900238q |
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