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Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-D-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase

The last two steps in the biosynthesis of riboflavin, an essential metabolite that is involved in electron transport, are catalyzed by lumazine synthase and riboflavin synthase. In order to obtain structural probes and inhibitors of these two enzymes, two ribityllumazinediones bearing alkyl phosphat...

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Detalhes bibliográficos
Main Authors: Cushman, Mark, Jin, Guangyi, Illarionov, Boris, Fischer, Markus, Ladenstein, Rudolf, Bacher, Adelbert
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2548293/
https://ncbi.nlm.nih.gov/pubmed/16277343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo051332v
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