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Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-D-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase

The last two steps in the biosynthesis of riboflavin, an essential metabolite that is involved in electron transport, are catalyzed by lumazine synthase and riboflavin synthase. In order to obtain structural probes and inhibitors of these two enzymes, two ribityllumazinediones bearing alkyl phosphat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cushman, Mark, Jin, Guangyi, Illarionov, Boris, Fischer, Markus, Ladenstein, Rudolf, Bacher, Adelbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2548293/
https://ncbi.nlm.nih.gov/pubmed/16277343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo051332v
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