Animal Models of Inflammasomopathies Reveal Roles for Innate but not Adaptive Immunity

Cryopyrin (NALP3) mediates formation of the inflammasome, a protein complex responsible for cleavage of pro-IL-1β to its active form. Mutations in the cryopyrin gene, NLRP3, cause the autoinflammatory disease spectrum: cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1β in CAPS...

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Main Authors: Brydges, Susannah D, Mueller, James L, McGeough, Matthew D, Pena, Carla A, Misaghi, Amirhossein, Gandhi, Chhavi, Putnam, Chris D, Boyle, David L, Firestein, Gary S, Horner, Anthony A, Soroosh, Pejman, Watford, Wendy T, O’Shea, John J, Kastner, Daniel L, Hoffman, Hal M
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759865/
https://ncbi.nlm.nih.gov/pubmed/19501000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.005
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