Animal Models of Inflammasomopathies Reveal Roles for Innate but not Adaptive Immunity

Cryopyrin (NALP3) mediates formation of the inflammasome, a protein complex responsible for cleavage of pro-IL-1β to its active form. Mutations in the cryopyrin gene, NLRP3, cause the autoinflammatory disease spectrum: cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1β in CAPS...

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Main Authors:	Brydges, Susannah D, Mueller, James L, McGeough, Matthew D, Pena, Carla A, Misaghi, Amirhossein, Gandhi, Chhavi, Putnam, Chris D, Boyle, David L, Firestein, Gary S, Horner, Anthony A, Soroosh, Pejman, Watford, Wendy T, O’Shea, John J, Kastner, Daniel L, Hoffman, Hal M
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2759865/ https://ncbi.nlm.nih.gov/pubmed/19501000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.005
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Animal Models of Inflammasomopathies Reveal Roles for Innate but not Adaptive Immunity

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