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Shedding Light on Proteolytic Cleavage of CD44: The Responsible Sheddase and Functional Significance of Shedding
CD44 is the major cell-surface receptor for hyaluronan, which is implicated in cell–cell and cell–matrix adhesion, cell migration, and signaling. Studies have shown that CD44-dependent migration requires CD44 to be shed from the cell surface and that matrix metalloproteinase–mediated cleavage may pr...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759693/ https://ncbi.nlm.nih.gov/pubmed/19434087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2009.13 |
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