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Sequence and Structure Signatures of Cancer Mutation Hotspots in Protein Kinases

Protein kinases are the most common protein domains implicated in cancer, where somatically acquired mutations are known to be functionally linked to a variety of cancers. Resequencing studies of protein kinase coding regions have emphasized the importance of sequence and structure determinants of c...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dixit, Anshuman, Yi, Lin, Gowthaman, Ragul, Torkamani, Ali, Schork, Nicholas J., Verkhivker, Gennady M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759519/
https://ncbi.nlm.nih.gov/pubmed/19834613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007485
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