Inhibition of indoleamine 2, 3-dioxygenase-mediated tryptophan catabolism accelerates crescentic glomerulonephritis

Immunomodulatory enzyme indoleamine 2, 3-dioxygenase (IDO) is one of the initial and rate-limiting enzymes involved in the catabolism of the essential amino acid tryptophan. Via catalysing tryptophan degradation, IDO suppresses adaptive T cell-mediated immunity and plays an important role in various...

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Autori principali: Hou, Weiping, Li, Suzhi, Wu, Yinping, Du, Xiang, Yuan, Fahuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2009
Soggetti:
Animal Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759486/
https://ncbi.nlm.nih.gov/pubmed/19302241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2009.03902.x
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