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A Thermodynamic Approach to the Affinity Optimization of Drug Candidates
High throughput screening and other techniques commonly used to identify lead candidates for drug development usually yield compounds with binding affinities to their intended targets in the mid-micromolar range. The affinity of these molecules needs to be improved by several orders of magnitude bef...
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| Hoofdauteur: | |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759410/ https://ncbi.nlm.nih.gov/pubmed/19793186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2009.00880.x |
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