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PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major

Leishmania must survive oxidative stress, but lack many classical antioxidant enzymes and rely heavily on trypanothione-dependent pathways. We used forward genetic screens to recover loci mediating oxidant resistance via overexpression in Leishmania major, which identified pteridine reductase 1 (PTR...

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Sonraí Bibleagrafaíochta
Main Authors: Nare, Bakela, Garraway, Levi A., Vickers, Tim J., Beverley, Stephen M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759280/
https://ncbi.nlm.nih.gov/pubmed/19396443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00294-009-0244-z
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