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PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major

Leishmania must survive oxidative stress, but lack many classical antioxidant enzymes and rely heavily on trypanothione-dependent pathways. We used forward genetic screens to recover loci mediating oxidant resistance via overexpression in Leishmania major, which identified pteridine reductase 1 (PTR...

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Bibliografiska uppgifter
Huvudupphovsmän: Nare, Bakela, Garraway, Levi A., Vickers, Tim J., Beverley, Stephen M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759280/
https://ncbi.nlm.nih.gov/pubmed/19396443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00294-009-0244-z
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