THE ENZYMES OF THE 10-FORMYL-TETRAHYDROFOLATE SYNTHETIC PATHWAY ARE FOUND EXCLUSIVELY IN THE CYTOSOL OF THE TRYPANOSOMATID PARASITE LEISHMANIA MAJOR

In most organisms 10-formyl-tetrahydrofolate (10-CHO-THF) participates in the synthesis of purines in the cytosol and formylation of mitochondrial initiator methionyl-tRNA(Met). Here we studied 10-CHO-THF biosynthesis in the protozoan parasite Leishmania major, a purine auxotroph. Two distinct synth...

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Hlavní autoři: Vickers, Tim J., Murta, Silvane M. F., Mandell, Michael A., Beverley, Stephen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692634/
https://ncbi.nlm.nih.gov/pubmed/19450731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2009.03.009
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