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Mitochondrial dysfunction leads to nuclear genome instability: A link through iron-sulfur clusters
Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the nuclear genome, are involved in multiple human diseases. Here we report that in Saccharomyces cerevisiae, loss of mtDNA leads to nuclear genome instability, through a process of cell cycle arrest and selection...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759275/ https://ncbi.nlm.nih.gov/pubmed/19563757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.04.014 |
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