Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability

Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of t...

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Main Authors: Díaz de la Loza, María del Carmen, Gallardo, Mercedes, García-Rubio, María Luisa, Izquierdo, Alicia, Herrero, Enrique, Aguilera, Andrés, Wellinger, Ralf Erik
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152343/
https://ncbi.nlm.nih.gov/pubmed/21511814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr193
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