Novel Lipoxygenase Inhibitors as Neuroprotective Reagents

The lipid-metabolizing enzyme 12/15-lipoxygenase (12/15-LOX) mediates cell death resulting from oxidative stress in both neurons and oligodendrocytes. Specifically, it may contribute to the pathophysiology of stroke and Alzheimer's and Parkinson's diseases. We report here that two of three...

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Main Authors: van Leyen, Klaus, Arai, Ken, Jin, Guang, Kenyon, Victor, Gerstner, Bettina, Rosenberg, Paul A., Holman, Theodore R., Lo, Eng H.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759176/
https://ncbi.nlm.nih.gov/pubmed/17960827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.21543
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