Differentiation of 3-O-Sulfated Heparin Disaccharide Isomers: Identification of Structural Aspects of the Heparin CCL2 Binding Motif

The presence of 3-O-sulfated glucosamine residues in heparin or heparan sulfate plays a role in binding to antithrombin III and HSV infection. In this study, tandem mass spectrometry was used to differentiate between two heparin disaccharide isomers containing variable sulfate at C6 in a common disa...

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Bibliographic Details
Main Authors: Meissen, John K., Sweeney, Matthew D., Girardi, Matthew, Lawrence, Roger, Esko, Jeffrey D., Leary, Julie A.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758813/
https://ncbi.nlm.nih.gov/pubmed/19185514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jasms.2008.12.002
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