XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis (fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) stress in the disease process via a pathway known as the unfolded protein response (UPR). Here, we investigated the contribution...

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Detalhes bibliográficos
Principais autores: Hetz, Claudio, Thielen, Peter, Matus, Soledad, Nassif, Melissa, Court, Felipe, Kiffin, Roberta, Martinez, Gabriela, Cuervo, Ana María, Brown, Robert H., Glimcher, Laurie H.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758741/
https://ncbi.nlm.nih.gov/pubmed/19762508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1830709
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