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L337H Mutant of Rat Neuronal Nitric Oxide Synthase Resembles Human Neuronal Nitric Oxide Synthase Toward Inhibitors

A common dichotomy exists in inhibitor design: should the compounds be designed to block the enzymes of animals in the preclinical studies or to inhibit the human enzyme? We report that a single mutation of Leu-337 in rat neuronal nitric oxide synthase (nNOS) to His makes the enzyme resemble human n...

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Autori principali: Fang, Jianguo, Ji, Haitao, Lawton, Graham R., Xue, Fengtian, Roman, Linda J., Silverman, Richard B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758698/
https://ncbi.nlm.nih.gov/pubmed/19537690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900380j
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