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Activation of PyMT in β Cells Induces Irreversible Hyperplasia, but Oncogene-Dependent Acinar Cell Carcinomas When Activated in Pancreatic Progenitors

It is unclear whether the cellular origin of various forms of pancreatic cancer involves transformation or transdifferentiation of different target cells or whether tumors arise from common precursors, with tumor types determined by the specific genetic alterations. Previous studies suggested that p...

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Detalhes bibliográficos
Main Authors: Du, Yi-Chieh Nancy, Klimstra, David S., Varmus, Harold
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758666/
https://ncbi.nlm.nih.gov/pubmed/19812721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006932
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