High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions

A substantial genetic contribution to systemic lupus erythematosus (SLE) risk is conferred by major histocompatibility complex (MHC) gene(s) on chromosome 6p21. Previous studies in SLE have lacked statistical power and genetic resolution to fully define MHC influences. We characterized 1,610 Caucasi...

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Main Authors: Barcellos, Lisa F., May, Suzanne L., Ramsay, Patricia P., Quach, Hong L., Lane, Julie A., Nititham, Joanne, Noble, Janelle A., Taylor, Kimberly E., Quach, Diana L., Chung, Sharon A., Kelly, Jennifer A., Moser, Kathy L., Behrens, Timothy W., Seldin, Michael F., Thomson, Glenys, Harley, John B., Gaffney, Patrick M., Criswell, Lindsey A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758598/
https://ncbi.nlm.nih.gov/pubmed/19851445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000696
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