High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions

A substantial genetic contribution to systemic lupus erythematosus (SLE) risk is conferred by major histocompatibility complex (MHC) gene(s) on chromosome 6p21. Previous studies in SLE have lacked statistical power and genetic resolution to fully define MHC influences. We characterized 1,610 Caucasi...

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Hlavní autoři: Barcellos, Lisa F., May, Suzanne L., Ramsay, Patricia P., Quach, Hong L., Lane, Julie A., Nititham, Joanne, Noble, Janelle A., Taylor, Kimberly E., Quach, Diana L., Chung, Sharon A., Kelly, Jennifer A., Moser, Kathy L., Behrens, Timothy W., Seldin, Michael F., Thomson, Glenys, Harley, John B., Gaffney, Patrick M., Criswell, Lindsey A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758598/
https://ncbi.nlm.nih.gov/pubmed/19851445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000696
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