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Selectivity and therapeutic inhibition of kinases: to be or not to be?
Protein kinases, which serve critical functions in signaling pathways in all cells, are popular therapeutic targets. At present, eight kinase inhibitors have been approved in the United States, each of which shows nanomolar potency. Although the initial goal was to generate inhibitors with a high de...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758543/ https://ncbi.nlm.nih.gov/pubmed/19295632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1701 |
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