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Kinase inhibitors in the treatment of immune-mediated disease

Protein kinases are fundamental components of diverse signaling pathways, including immune cells. Their essential functions have made them effective therapeutic targets. Initially, the expectation was that a high degree of selectivity would be critical; however, with time, the use of “multikinase” i...

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Détails bibliographiques
Auteurs principaux: Kontzias, Apostolos, Laurence, Arian, Gadina, Massimo, O’Shea, John J.
Format: Artigo
Langue:Inglês
Publié: Faculty of 1000 Ltd 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297200/
https://ncbi.nlm.nih.gov/pubmed/22403586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3410/M4-5
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