Somatic Single-hits Inactivate the X-linked Tumor Suppressor FOXP3 in the Prostate

Despite clear epidemiological and genetic evidence for X-linked prostate cancer risk, all prostate cancer genes identified are autosomal. Here we report somatic inactivating mutations and deletion of the X-linked FOXP3 gene residing at Xp11.23 in human prostate cancer. Lineage-specific ablation of F...

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Detalhes bibliográficos
Main Authors: Wang, Lizhong, Liu, Runhua, Li, Weiquan, Chen, Chong, Katoh, Hiroto, Chen, Guo-Yun, McNally, Beth, Lin, Lin, Zhou, Penghui, Zuo, Tao, Cooney, Kathleen A., Liu, Yang, Zheng, Pan
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758294/
https://ncbi.nlm.nih.gov/pubmed/19800578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.08.016
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