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Inactivation of X-linked tumor suppressor genes in human cancer
Cancer cells silence autosomal tumor suppressor genes by Knudson’s two-hit mechanism in which loss-of-function mutations and then loss of heterozygosity occur at the tumor suppressor gene loci. However, the identification of X-linked tumor suppressor genes has challenged the traditional theory of “t...
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| Publicado no: | Future Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4369797/ https://ncbi.nlm.nih.gov/pubmed/22515449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.12.26 |
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