The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

The ubiquitin-mediated degradation of mitotic cyclins is required for cells to exit from mitosis. Previous work with cell-free systems has revealed four components required for cyclin-ubiquitin ligation and proteolysis: a nonspecific ubiquitin-activating enzyme E1, a soluble fraction containing a ub...

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Udgivet i:	Mol Biol Cell
Principais autores:	Sudakin, V, Ganoth, D, Dahan, A, Heller, H, Hershko, J, Luca, F C, Ruderman, J V, Hershko, A
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Cell Biology 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC275828/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7787245/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.6.2.185
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