Stepwise in vitro affinity maturation of Vitaxin, an α(v)β(3)-specific humanized mAb

A protein engineering strategy based on efficient and focused mutagenesis implemented by codon-based mutagenesis was developed. Vitaxin, a humanized version of the antiangiogenic antibody LM609 directed against a conformational epitope of the α(v)β(3) integrin complex, was used as a model system. Sp...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wu, Herren, Beuerlein, Gregory, Nie, Ying, Smith, Heidi, Lee, Bruce A., Hensler, Mary, Huse, William D., Watkins, Jeffry D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27581/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600913/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.6037
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