Stepwise in vitro affinity maturation of Vitaxin, an α(v)β(3)-specific humanized mAb
A protein engineering strategy based on efficient and focused mutagenesis implemented by codon-based mutagenesis was developed. Vitaxin, a humanized version of the antiangiogenic antibody LM609 directed against a conformational epitope of the α(v)β(3) integrin complex, was used as a model system. Sp...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Proc Natl Acad Sci U S A |
|---|---|
| Prif Awduron: | , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
National Academy of Sciences
1998
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27581/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600913/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.6037 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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