Stepwise in vitro affinity maturation of Vitaxin, an α(v)β(3)-specific humanized mAb
A protein engineering strategy based on efficient and focused mutagenesis implemented by codon-based mutagenesis was developed. Vitaxin, a humanized version of the antiangiogenic antibody LM609 directed against a conformational epitope of the α(v)β(3) integrin complex, was used as a model system. Sp...
I tiakina i:
| I whakaputaina i: | Proc Natl Acad Sci U S A |
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| Ngā kaituhi matua: | , , , , , , , |
| Hōputu: | Artigo |
| Reo: | Inglês |
| I whakaputaina: |
National Academy of Sciences
1998
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| Ngā marau: | |
| Urunga tuihono: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27581/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600913/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.6037 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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