GOSPEL: A novel neuroprotective protein that binds to GAPDH upon S-nitrosylation

We recently reported a novel cell death cascade whereby cellular stressors activate nitric oxide formation leading to S-nitrosylation of GAPDH that binds to Siah and translocates to the nucleus. The nuclear GAPDH/Siah complex augments p300/CBP-associated acetylation of nuclear proteins, including p5...

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Autori principali: Sen, Nilkantha, Hara, Makoto R., Ahmed, Abdullah Shafique, Cascio, Matthew B., Kamiya, Atsushi, Ehmsen, Jeffrey T., Aggrawal, Nishant, Hester, Lynda, Dore, Sylvain, Snyder, Solomon H., Sawa, Akira
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758064/
https://ncbi.nlm.nih.gov/pubmed/19607794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.05.024
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