NANOG is a Direct Target of TGFβ/Activin Mediated SMAD Signaling in Human ES Cells

Self-renewal of human embryonic stem (ES) cells is promoted by FGF and TGFβ/Activin signaling, and differentiation is promoted by BMP signaling, but how these signals regulate genes critical to the maintenance of pluripotency has been unclear. Using a defined medium, we show here that both TGFβ and...

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Autori principali: Xu, Ren-He, Barron, Tori L., Gu, Feng, Root, Sierra, Peck, Ruthann M., Pan, Guangjin, Yu, Junying, Antosiewicz-Bourget, Jessica, Tian, Shulan, Stewart, Ron, Thomson, James A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758041/
https://ncbi.nlm.nih.gov/pubmed/18682241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.07.001
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