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FGF2 Sustains NANOG and Switches the Outcome of BMP4 Induced Human Embryonic Stem Cell Differentiation

Here we show that as human embryonic stem (ES) cells exit the pluripotent state, NANOG can play a key role in determining lineage outcome. It has previously been reported that BMPs induce differentiation of human ES cells into extraembryonic lineages. Here we find that FGF2, acting through the MEK-E...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Yu, Pengzhi, Pan, Guangjin, Yu, Junying, Thomson, James A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052735/
https://ncbi.nlm.nih.gov/pubmed/21362572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2011.01.001
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