Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes: SUCCINATION INHIBITS POLYMERIZATION AND SECRETION OF ADIPONECTIN

S-(2-Succinyl)cysteine (2SC) is formed by reaction of the Krebs cycle intermediate fumarate with cysteine residues in protein, a process termed succination of protein. Both fumarate and succination of proteins are increased in adipocytes cultured in high glucose medium (Nagai, R., Brock, J. W., Blat...

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Main Authors: Frizzell, Norma, Rajesh, Mathur, Jepson, Matthew J., Nagai, Ryoji, Carson, James A., Thorpe, Suzanne R., Baynes, John W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Protein Synthesis, Post-Translational Modification, and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757979/
https://ncbi.nlm.nih.gov/pubmed/19592500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.019257
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