Aldosterone Increases Oxidant Stress to Impair Guanylyl Cyclase Activity by Cysteinyl Thiol Oxidation in Vascular Smooth Muscle Cells

Hyperaldosteronism is associated with impaired endothelium-dependent vascular reactivity owing to increased reactive oxygen species and decreased bioavailable nitric oxide (NO(·)); however, the effects of aldosterone on vasodilatory signaling pathways in vascular smooth muscle cells (VSMC) remain un...

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Detalhes bibliográficos
Main Authors: Maron, Bradley A., Zhang, Ying-Yi, Handy, Diane E., Beuve, Annie, Tang, Shiow-Shih, Loscalzo, Joseph, Leopold, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658060/
https://ncbi.nlm.nih.gov/pubmed/19141618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809460200
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