Rapid and Efficient Synthesis of Succinated Thiol Compounds via Maleic Anhydride Derivatization

Succination is a non-enzymatic post-translational modification of cysteine (Cys) residues, resulting in the formation of <i>S</i>-(2-succino)cysteine (2SC). While hundreds of 2SC-modified proteins have been identified and are associated with the dysfunction of proteins, the underlying mo...

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Hlavní autoři: Hiroshi Yamaguchi, Hikari Sugawa, Himeno Takahashi, Ryoji Nagai
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2025-01-01
Edice:Molecules
Témata:
succination
maleic anhydride
thiol compound
Michael addition reaction
On-line přístup:https://www.mdpi.com/1420-3049/30/3/571
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