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Rapid and Efficient Synthesis of Succinated Thiol Compounds via Maleic Anhydride Derivatization

Succination is a non-enzymatic post-translational modification of cysteine (Cys) residues, resulting in the formation of <i>S</i>-(2-succino)cysteine (2SC). While hundreds of 2SC-modified proteins have been identified and are associated with the dysfunction of proteins, the underlying molecular mech...

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Principais autores: Hiroshi Yamaguchi, Hikari Sugawa, Himeno Takahashi, Ryoji Nagai
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2025-01-01
סדרה:Molecules
נושאים:
succination
maleic anhydride
thiol compound
Michael addition reaction
גישה מקוונת:https://www.mdpi.com/1420-3049/30/3/571
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