Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

Interferon regulatory factors (IRFs) are essential in the innate immune response and other physiological processes. Activation of these proteins in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal autoinhibitory region, which stimulates dimerization, transport into t...

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Библиографические подробности
Главные авторы: Chen, Weijun, Lam, Suvana S., Srinath, Hema, Jiang, Zhaozhao, Correia, John J., Schiffer, Celia A., Fitzgerald, Katherine A., Lin, Kai, Royer, William E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757928/
https://ncbi.nlm.nih.gov/pubmed/18836453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1496
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