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Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5
Interferon regulatory factors (IRFs) are essential in the innate immune response and other physiological processes. Activation of these proteins in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal autoinhibitory region, which stimulates dimerization, transport into t...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757928/ https://ncbi.nlm.nih.gov/pubmed/18836453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1496 |
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