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Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci
The E2A gene products, E12 and E47, are critical regulators of B cell development. However, it remains elusive whether E12 and E47 have overlapping and/or distinct functions during B lymphopoiesis. We have generated mice deficient for either E12 or E47 and examined their roles in B cell maturation....
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757879/ https://ncbi.nlm.nih.gov/pubmed/19752184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090756 |
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