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A progenitor cell origin of myeloid malignancies

All cancers rely on cells that have properties of long-term self-renewal or “stemness” to maintain and propagate the tumor, but the cell of origin of most cancers is still unknown. Here, we design a stochastic mathematical model of hematopoietic stem and progenitor cells to study the evolutionary dy...

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Detalhes bibliográficos
Main Authors: Haeno, Hiroshi, Levine, Ross L., Gilliland, D. Gary, Michor, Franziska
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757818/
https://ncbi.nlm.nih.gov/pubmed/19805346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908107106
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