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Inhibition of K(Ca)2.2 and K(Ca)2.3 channel currents by protonation of outer pore histidine residues

Ion channels are often modulated by changes in extracellular pH, with most examples resulting from shifts in the ionization state of histidine residue(s) in the channel pore. The application of acidic extracellular solution inhibited expressed K(Ca)2.2 (SK2) and K(Ca)2.3 (SK3) channel currents, with...

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Bibliografische gegevens
Hoofdauteurs: Goodchild, Samuel J., Lamy, Cedric, Seutin, Vincent, Marrion, Neil V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757770/
https://ncbi.nlm.nih.gov/pubmed/19786583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200910252
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