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Contribution of IL12R mediated feedback loop to Th1 cell differentiation
T helper 1 cell fate is induced by overlapping signaling pathways, whose kinetic principles and regulatory motifs are largely unknown. We identified a simple positive feedback loop in the STAT4 signaling pathway, whereby activation by IL-12 leads to the increased expression in IL-12 receptor. A comp...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757731/ https://ncbi.nlm.nih.gov/pubmed/17950290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.10.007 |
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