Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells

BACKGROUND: Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes. METHODOLOGY/PRINCIPAL FINDINGS:...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Soh, Junichi, Okumura, Naoki, Lockwood, William W., Yamamoto, Hiromasa, Shigematsu, Hisayuki, Zhang, Wei, Chari, Raj, Shames, David S., Tang, Ximing, MacAulay, Calum, Varella-Garcia, Marileila, Vooder, Tõnu, Wistuba, Ignacio I., Lam, Stephen, Brekken, Rolf, Toyooka, Shinichi, Minna, John D., Lam, Wan L., Gazdar, Adi F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2009
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757721/
https://ncbi.nlm.nih.gov/pubmed/19826477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007464
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