Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells

BACKGROUND: Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes. METHODOLOGY/PRINCIPAL FINDINGS:...

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主要な著者: Soh, Junichi, Okumura, Naoki, Lockwood, William W., Yamamoto, Hiromasa, Shigematsu, Hisayuki, Zhang, Wei, Chari, Raj, Shames, David S., Tang, Ximing, MacAulay, Calum, Varella-Garcia, Marileila, Vooder, Tõnu, Wistuba, Ignacio I., Lam, Stephen, Brekken, Rolf, Toyooka, Shinichi, Minna, John D., Lam, Wan L., Gazdar, Adi F.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2009
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757721/
https://ncbi.nlm.nih.gov/pubmed/19826477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007464
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