Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells

BACKGROUND: Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes. METHODOLOGY/PRINCIPAL FINDINGS:...

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Bibliografiset tiedot
Päätekijät: Soh, Junichi, Okumura, Naoki, Lockwood, William W., Yamamoto, Hiromasa, Shigematsu, Hisayuki, Zhang, Wei, Chari, Raj, Shames, David S., Tang, Ximing, MacAulay, Calum, Varella-Garcia, Marileila, Vooder, Tõnu, Wistuba, Ignacio I., Lam, Stephen, Brekken, Rolf, Toyooka, Shinichi, Minna, John D., Lam, Wan L., Gazdar, Adi F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2009
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757721/
https://ncbi.nlm.nih.gov/pubmed/19826477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007464
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