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Acidic preconditioning protects endothelial cells against apoptosis through p38- and Akt-dependent Bcl-xL overexpression

To analyze the underlying cellular mechanisms of adaptation to ischemia-induced apoptosis through short acidic pretreatment, i.e. acidic preconditioning (APC), Wistar rat coronary endothelial cells (EC) were exposed for 40 min to acidosis (pH 6.4) followed by a 14 h recovery period (pH 7.4) and fina...

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Détails bibliographiques
Auteurs principaux: Flacke, Jan-Paul, Kumar, Sanjeev, Kostin, Sawa, Reusch, H. Peter, Ladilov, Yury
Format: Artigo
Langue:Inglês
Publié: Springer US 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757620/
https://ncbi.nlm.nih.gov/pubmed/19082728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-008-0287-5
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